Astellas Pharma Scientist II/Senior Scientist, HMC Product Development in Westborough, Massachusetts
The Astellas Institute of Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products.
Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company.
AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Marlborough, Massachusetts.
Astellas is announcing a Senior Scientist, HMC product development opportunity at their affiliate Astellas Institute of Regenerative Medicine (AIRM) in Westborough, MA.
The Sr. Scientist HMC product development (HMC is a PSC-derived MSC product) in accordance with the strategic goals of the team, utilizes scientific principles and methodologies to perform a variety of laboratory-based experiments and procedures. Coordinates research efforts and makes key technical contribution affecting the direction of the group and/or project. Applies expertise and breadth of knowledge to ongoing research and to the development of new projects.
Essential Job Responsibilities:
- Maintain multiple iPSC lines and routinely perform differentiation into mesoderm lineages
- Viral transduction/engineering of pluripotent stem cell lines and/or their derivatives
- Performs data collection, analysis, and interpretation of in vitro assays (e.g. flow cytometry, ICC, ELISA, RT-PCR) to characterize pluripotent stem cell populations and derivatives thereof
- Formulates and implements processes ensuring preservation of cellular quality attributes
- Isolates, cultures and characterizes primary immune cells from preclinical murine models
- Stays up to date on relevant literature and helps manage external collaborations
- Develops and adheres to SOPs and workflows with proper documentation
- Optimizes procedures as needed, effectively troubleshoots technical issues
- PhD. with 3+ years post-degree laboratory experience in developmental biology, cell biology, immunology or related biological life science
- Experience with human or mouse pluripotent stem cell culture (ESC or iPSC)
- Working knowledge of animal disease models with preference to autoimmune-related disorders
- Solid working knowledge of molecular and cell biology techniques and signaling pathways governing stem cell differentiation
- Excellent written, verbal communication and interpersonal skills.
- Excellent interpersonal skills and ability to work independently and collaborate within a team-based environment
- Firsthand experience with pluripotent stem cell differentiation into mesoderm lineages
- Strong background and interest in working with multiple in vivo, preclinical models
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Category Research and Development